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Since the main function of L-carnitine is to promote the -oxidation of long-chain fatty acids, this activity may increase lipocatabolic metabolism, thus increasing the cholesterol and triglyceride levels

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Some patients plateau temporarily between months 2 and 4 as their body adapts, which does not indicate treatment failure but rather a normal metabolic adjustment phase

Mouse models have been used to directly examine the contribution of MPO to atherosclerosis, although these studies carry the caveat that mouse MPO levels are only 10-20% that of humans (286,287)